Document Detail


Single thawed euploid embryo transfer improves IVF pregnancy, miscarriage, and multiple gestation outcomes and has similar implantation rates as egg donation.
MedLine Citation:
PMID:  23307447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The objective of our study was to determine if trophectoderm biopsy, vitrification, array-comparative genomic hybridization and single thawed euploid embryo transfer (STEET) can reduce multiple gestations and yield high pregnancy and low miscarriage rates.
METHODS: We performed a retrospective observational study comparing single thawed euploid embryo to routine age matched in vitro fertilization (IVF) patients that underwent blastocyst transfer from 2008 to 2011 and to our best prognosis group donor oocyte recipients (Donor). Our main outcome measures were implantation rate, clinical pregnancy rate, spontaneous abortion rate and multiple gestation rate.
RESULTS: The STEET group had a significantly higher implantation rate (58 %, 53/91) than the routine IVF group (39 %, 237/613) while the Donor group (57 %, 387/684) had a similar implantation rate. The clinical pregnancy rates were not statistically different between the STEET and IVF groups. However, the multiple gestation rate was significantly lower in the STEET group (STEET 2 % versus IVF 34 %, Donor 47 %).
CONCLUSIONS: STEET results in a high pregnancy rate, low multiple gestation rate and miscarriage rates. Despite the older age of STEET patients and transfer of twice as many embryos, the implantation rate for STEET was indistinguishable from that for egg donation. STEET offers an improvement to IVF, lowering risks without compromising pregnancy rate.
Authors:
Jamie A Grifo; Brooke Hodes-Wertz; Hsiao-Ling Lee; Esmeralda Amperloquio; Melicia Clarke-Williams; Alexis Adler
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Publication Detail:
Type:  Journal Article     Date:  2013-01-11
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  30     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-03     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / therapy
Adult
Biopsy
Comparative Genomic Hybridization
Cryopreservation
Ectoderm
Embryo Implantation / physiology*
Female
Fertilization in Vitro*
Humans
Oocyte Donation
Pregnancy
Pregnancy Outcome
Pregnancy, Multiple / physiology
Single Embryo Transfer*
Vitrification
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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