| Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(II) terpyridyl complexes. | |
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MedLine Citation:
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PMID: 17179048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(II) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal...metal and pi...pi stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids. |
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Authors:
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Cong Yu; Kenneth Hoi-Yiu Chan; Keith Man-Chung Wong; Vivian Wing-Wah Yam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-18 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 103 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-27 Completed Date: 2007-02-08 Revised Date: 2010-09-16 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 19652-7 Citation Subset: IM |
Affiliation:
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Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Nucleic Acid Conformation Nucleic Acids / chemistry* Organoplatinum Compounds / chemistry* Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids; 0/Organoplatinum Compounds |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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