Document Detail


Single-strand conformation polymorphism analysis for the study of adenoviral diversity in urban rivers.
MedLine Citation:
PMID:  20117139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diversity of human adenoviruses (AdVs) in river waters was studied by single-strand conformational polymorphism (SSCP) analysis. Water samples were collected between 2002 and 2003 from 4 rivers in the Gyeonggi Province, South Korea. Forty-six (79.3%) of the 58 samples were positive for AdVs as determined on PCR amplification. Nine different SSCP profiles (profiles A to I) were detected in all the AdVs-positive samples by SSCP analysis, and most of the AdVs-positive samples (38 of 46 samples; 82.6%) showed the SSCP profile D. Nine different sequences were obtained in the SSCP profiles; sequence alignments and phylogenetic analysis identified 5 different sequences that were closely related to the human AdV type 41, and the 4 different sequences that were closely related to human AdV types 3, 4, 12, and 40. Two AdVs genomic variants were detected (types 3 and 41 in A, types 12 and 41 in B, and 2 genomic variants of type 41 in C) in SSCP profiles A, B, and C, respectively. SSCP analysis could be a useful technique for the identification of genetic variants of AdVs and for studying AdVs diversity in urban rivers.
Authors:
Cheonghoon Lee; Sang-Jong Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-29
Journal Detail:
Title:  Journal of virological methods     Volume:  165     ISSN:  1879-0984     ISO Abbreviation:  J. Virol. Methods     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005839     Medline TA:  J Virol Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, South Korea.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/GQ477371;  GQ477372;  GQ477373;  GQ477374;  GQ477375;  GQ477376;  GQ477377;  GQ477378;  GQ477379
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MeSH Terms
Descriptor/Qualifier:
Adenoviruses, Human / classification*,  genetics
Base Sequence
Environmental Monitoring / methods*
Humans
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational*
Republic of Korea
Rivers / virology*
Water Microbiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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