Document Detail


Single-scan dual-tracer FLT+FDG PET tumor characterization.
MedLine Citation:
PMID:  23296314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rapid multi-tracer PET aims to image two or more tracers in a single scan, simultaneously characterizing multiple aspects of physiology and function without the need for repeat imaging visits. Using dynamic imaging with staggered injections, constraints on the kinetic behavior of each tracer are applied to recover individual-tracer measures from the multi-tracer PET signal. The ability to rapidly and reliably image both (18)F-fluorodeoxyglucose (FDG) and (18)F-fluorothymidine (FLT) would provide complementary measures of tumor metabolism and proliferative activity, with important applications in guiding oncologic treatment decisions and assessing response. However, this tracer combination presents one of the most challenging dual-tracer signal-separation problems--both tracers have the same radioactive half-life, and the injection delay is short relative to the half-life and tracer kinetics. This work investigates techniques for single-scan dual-tracer FLT+FDG PET tumor imaging, characterizing the performance of recovering static and dynamic imaging measures for each tracer from dual-tracer datasets. Simulation studies were performed to characterize dual-tracer signal-separation performance for imaging protocols with both injection orders and injection delays of 10-60 min. Better performance was observed when FLT was administered first, and longer delays before administration of FDG provided more robust signal-separation and recovery of the single-tracer imaging measures. An injection delay of 30 min led to good recovery (R > 0.96) of static image values (e.g. SUV), K(net), and K(1) as compared to values from separate, single-tracer time-activity curves. Recovery of higher order rate parameters (k(2), k(3)) was less robust, indicating that information regarding these parameters was harder to recover in the presence of statistical noise and dual-tracer effects. Performance of the dual-tracer FLT(0 min)+FDG(32 min) technique was further evaluated using PET/CT imaging studies in five patients with primary brain tumors where the data from separate scans of each tracer were combined to synthesize dual-tracer scans with known single-tracer components; results demonstrated similar dual-tracer signal recovery performance. We conclude that rapid dual-tracer FLT+FDG tumor imaging is feasible and can provide quantitative tumor imaging measures comparable to those from conventional separate-scan imaging.
Authors:
Dan J Kadrmas; Thomas C Rust; John M Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  Physics in medicine and biology     Volume:  58     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-06-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  429-49     Citation Subset:  IM    
Affiliation:
Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, USA. kadrmas@ucair.med.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / radionuclide imaging*
Clinical Trials as Topic
Dideoxynucleosides / diagnostic use*
Feasibility Studies
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Image Processing, Computer-Assisted
Injections
Positron-Emission Tomography / methods*
Time Factors
Grant Support
ID/Acronym/Agency:
3P30CA042014/CA/NCI NIH HHS; R01 CA135556/CA/NCI NIH HHS; R01CA135556/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Dideoxynucleosides; 63503-12-8/Fluorodeoxyglucose F18; PG53R0DWDQ/alovudine
Comments/Corrections

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