Document Detail

Single reading with computer-aided detection and double reading of screening mammograms in the United Kingdom National Breast Screening Program.
MedLine Citation:
PMID:  16990670     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To retrospectively determine if the use of a computer-aided detection (CAD) system can improve the performance of single reading of screening mammograms to match that of double reading in the United Kingdom. MATERIALS AND METHODS: Local research ethics committee approval was obtained; informed consent was not required. This study included a sample of 10 267 mammograms obtained in women aged 50 years or older who underwent routine screening at one of two breast screening centers in 1996. Mammograms that were double read in 1996 were randomly allocated to be re-read by eight different radiologists using CAD. The cancer detection and recall rates from double reading and single reading with CAD were compared. Statistical significance and confidence intervals were calculated with the McNemar test to account for the matched nature of the data. RESULTS: Single reading with CAD led to a cancer detection rate that was significantly (P = .02) higher than that achieved with double reading: 6.5% more cancers were detected by means of single reading with CAD than by means of double reading. However, the recall rate was higher for single reading with CAD than for double reading (8.6% vs 6.5%, respectively; P < .001). This was equivalent to relative increases of 15% and 32% in the cancer detection and recall rates, respectively. CONCLUSION: Single reading with CAD leads to an improved cancer detection rate and an increased recall rate.
Fiona J Gilbert; Susan M Astley; Magnus A McGee; Maureen G C Gillan; Caroline R M Boggis; Pamela M Griffiths; Stephen W Duffy
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  241     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-53     Citation Subset:  AIM; IM    
Copyright Information:
(c) RSNA, 2006.
Department of Radiology, University of Aberdeen, Lilian Sutton Bldg, Foresterhill, Aberdeen, Scotland.
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MeSH Terms
Breast Neoplasms / radiography
Government Programs
Great Britain
Image Processing, Computer-Assisted*
Mammography / methods*
Middle Aged
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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