Document Detail


Single photon emission computed tomography (SPECT) brain imaging using N,N,N'-trimethyl-N'-(2 hydroxy-3-methyl-5-123I-iodobenzyl)-1,3-propanediamine 2 HCl (HIPDM): intractable complex partial seizures.
MedLine Citation:
PMID:  3489907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIPDM-SPECT brain imaging was performed in four patients with intractable complex partial seizures (CPS). Three patients had an epileptogenic focus in one temporal lobe and underwent anterior temporal lobectomy. Interictal HIPDM-SPECT demonstrated decreased regional cerebral perfusion (rCP) in the epileptogenic area in only one patient, but ictal studies showed increased rCP in the epileptic foci of all three patients. In the fourth patient, interictal HIPDM-SPECT showed increased rCP in the area of epileptogenic focus; when antiepileptic medication was taken, rCP decreased. HIPDM-SPECT brain imaging is useful for localizing epileptogenic foci in CPS.
Authors:
B I Lee; O N Markand; A R Siddiqui; H M Park; B Mock; H H Wellman; R M Worth; M K Edwards
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  36     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-11-21     Completed Date:  1986-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1471-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / radionuclide imaging*
Cerebrovascular Circulation
Epilepsy, Temporal Lobe / radionuclide imaging*
Female
Humans
Iodobenzenes / diagnostic use*
Male
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
0/Iodobenzenes; 84718-97-8/N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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