| Single-operator comparison of early and mid-second-trimester amniocentesis. | |
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MedLine Citation:
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PMID: 1579318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to determine whether early amniocentesis is a safe and acceptable method of genetic evaluation in early pregnancy. During the 54-month period from September 1986 to February 1991, 300 consecutive early second-trimester amniocenteses were performed transabdominally at 13-14 weeks' gestation and 567 consecutive mid-second-trimester transabdominal amniocenteses were performed at 16-18 weeks. Group assignment was nonrandomized, interoperator-dependent variables were eliminated, and analysis was performed in one cytogenetics laboratory. The median maternal age and indications for the procedure were similar in both groups. There were no significant differences between the early- and mid-second-trimester amniocenteses in failed sampling, ambiguous results, pregnancy loss from 4 weeks after the procedure to 28 weeks' gestation, preterm birth, or perinatal death rate. Pregnancy loss within 4 weeks of amniocentesis was more frequent in early- than in mid-second-trimester amniocenteses. We conclude that early amniocentesis is a safe and acceptable method of genetic evaluation. |
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Authors:
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B G Assel; S M Lewis; L H Dickerman; V M Park; M N Jassani |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 79 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-06-08 Completed Date: 1992-06-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 940-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Reproductive Biology, University MacDonald Womens Hospital, Case Western Reserve University, Cleveland, Ohio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis / adverse effects, standards* Chromosome Aberrations / diagnosis* Chromosome Disorders Culture Techniques Female Fetal Death Genetic Testing Humans Karyotyping Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second |
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