Document Detail


Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.
MedLine Citation:
PMID:  21643756     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purinergic 1 receptor (P2RY1) has been implicated in development of heart disease and in individual pharmacodynamic response to anticoagulant therapies. However, the association of polymorphisms in the P2RY1 gene with myocardial infarction (MI), and its associated conditions, has yet to be reported in the literature. We evaluated seven known SNPs in P2RY1 for association with MI in a Latvian population. Seven independent parameters that are related to MI [body mass index (BMI), type 2 diabetes (T2D), angina pectoris, hypertension, hyperlipidemia, atrial fibrillation and heart failure] were investigated. No significant association with MI was observed for any of the polymorphisms. Those SNPs for which the P value was close to significance were located in coding or promoter regions. Intriguingly, carriers of the minor allele in the P2RY1 gene locus showed a tendency towards higher onset age for MI, suggesting a possible protective effect of these SNPs against MI or their contribution in progression as opposed to onset. Finally, a linkage disequilibrium (LD) plot was generated for these polymorphisms in the Latvian population. The results of this study suggest that the role of P2RY1 in individuals from Latvian population is likely to be principally involved in platelet aggregation and thromboembolic diseases, and not as a significant contributing factor to the global metabolic syndrome.
Authors:
Vita Ignatovica; Gustavs Latkovskis; Raitis Peculis; Kaspars Megnis; Helgi B Schioth; Iveta Vaivade; Davids Fridmanis; Valdis Pirags; Andrejs Erglis; Janis Klovins
Related Documents :
22122456 - Assessment of cardiac safety for pparγ agonists in rodent models of heart failure: a t...
12414546 - Ethanol modulates coronary permeability to macromolecules in murine aids.
158976 - Idiopathic hypertrophic subaortic stenosis: evaluation of anginal symptoms with thalliu...
15529916 - A reverse perfusion pattern during technetium-99m stress myocardial perfusion imaging d...
8993816 - Use of intravascular ultrasound in evaluating repeated balloon rupture during coronary ...
19004376 - A canine model of sustained atrial fibrillation induced by rapid atrial pacing and phen...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-4
Journal Detail:
Title:  Molecular biology reports     Volume:  -     ISSN:  1573-4978     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Latvian Biomedical Research and Study Centre, Ratsupites str. 1, Riga, 1067, Latvia, vita.ignatovica@biomed.lu.lv.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride i...
Next Document:  Association between C1431T polymorphism in peroxisome proliferator-activated receptor-? gene and cor...