| Single nucleotide polymorphisms in inflammatory genes and the risk of early onset of lone atrial fibrillation. | |
| | |
MedLine Citation:
|
PMID: 20490891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Systemic low-grade inflammation is a prognostic risk factor of atrial fibrillation (AF). OBJECTIVE: We hypothesized that genetic polymorphisms, which determine the rate of inflammatory cytokines, are associated with the risk of AF, independently of comorbidity. METHODS AND RESULTS: We included 192 patients with so-called lone AF and age 40 years or below, and 188 healthy controls. All patients were genotyped for single nucleotide polymorphisms (SNPs) in inflammatory genes using fluorescence-based real-time polymerase chain reaction (PCR). A case-control analysis of the C/C, C/T and T/T genotypes on IL1A-889 revealed a significant difference in both the frequency of genotypes (p = 0.03) and in the allelic frequency (p = 0.015). These differences were not significant after Bonferroni corrections. For IL1B-511, IL10-592, IL10-1082, IL18-137, IL18-607 and TNF-308 there were no significant differences, neither in genotype frequency, nor in allelic frequency between the lone AF patients and the controls. CONCLUSION: Our study failed to show an association between polymorphisms in inflammatory genes and early onset of lone AF. It remains to be established whether polymorphisms in inflammatory genes play a causative role in the pathophysiology of AF. |
| | |
Authors:
|
Kristoffer M A Henningsen; Morten S Olesen; Maria Pedersen; Lone Nielsen; Stig Haunsø; Helle Bruunsgaard; Jesper Hastrup Svendsen |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-20 |
Journal Detail:
|
Title: Inflammation research : official journal of the European Histamine Research Society ... [et al.] Volume: 59 ISSN: 1420-908X ISO Abbreviation: Inflamm. Res. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9508160 Medline TA: Inflamm Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 965-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Atrial Fibrillation* / etiology, genetics Cytokines / genetics*, immunology Gene Frequency Genetic Predisposition to Disease* Genotype Humans Inflammation* / complications, genetics Male Polymorphism, Single Nucleotide* Risk Factors Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Soluble CD40L (CD154) is increased in patients with shock.
Next Document: Differential dose effects of recombinant IL-25 on the development of dextran sulfate sodium-induced ...