Document Detail


Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows.
MedLine Citation:
PMID:  21948746     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The somatotrophic axis (GH-IGF) is a key regulator of animal growth and development, affecting performance traits that include milk production, growth rate, body composition, and fertility. The aim of this study was to quantify the association of previously identified SNPs in bovine growth hormone (GH1) and insulin-like growth factor 1 (IGF-1) genes with direct performance trait measurements of lactation and fertility in Holstein-Friesian lactating dairy cows. Sixteen SNPs in both IGF-1 and GH1 were genotyped across 610 cows and association analyses were carried out with traits of economic importance including calving interval, pregnancy rate to first service and 305-day milk production, using animal linear mixed models accounting for additive genetic effects. Two IGF-1 SNPs, IGF1i1 and IGF1i2, were significantly associated with body condition score at calving, while a single IGF-1 SNP, IGF1i3, was significantly associated with milk production, including milk yield (means ± SEM; 751.3 ± 262.0 kg), fat yield (21.3 ± 10.2 kg) and protein yield (16.5 ± 8.0 kg) per lactation. Only one GH1 SNP, GH33, was significantly associated with milk protein yield in the second lactation (allele substitution effect of 9.8 ± 5.0 kg). Several GH1 SNPs were significantly associated with fertility, including GH32, GH35 and GH38 with calving to third parity (22.4 ± 11.3 days) (GH32 and GH38 only), pregnancy rate to first service (0.1%) and overall pregnancy rate (0.05%). The results of this study demonstrate the effects of variants of the somatotrophic axis on milk production and fertility traits in commercial dairy cattle.
Authors:
M P Mullen; C O Lynch; S M Waters; D J Howard; P O'Boyle; D A Kenny; F Buckley; B Horan; M G Diskin
Related Documents :
21768866 - Uterine dehiscence in early second trimester.
21722896 - Conjoined twins after intracytoplasmic sperm injection and transfer of day-3 embryos.
21864206 - Relationship between processed total motile sperm count of husband or donor semen and p...
21824716 - Hydrosalpinx and infertility: what about conservative surgical management?
19205446 - Spontaneous uterine rupture during preterm labor in the second trimester of a twin ivf ...
3535366 - Hydatidiform mole in a triplet pregnancy following gonadotropin therapy.
Publication Detail:
Type:  Journal Article     Date:  2011-08-26
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  10     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1819-30     Citation Subset:  IM    
Affiliation:
Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Athenry, Co. Galway michael.mullen@teagasc.ie.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Proteomic and bioinformatic analysis of outer membrane proteins of the protobacterium Bartonella hen...
Next Document:  Variability of red rot-resistant somaclones of sugarcane genotype S97US297 assessed by RAPD and SSR.