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Single nucleotide polymorphism (SNP) associations with preterm delivery: a case-control replication study and meta-analysis.
MedLine Citation:
PMID:  23835654     Owner:  NLM     Status:  Publisher    
Background:To replicate single nucleotide polymorphism (SNP) associations with preterm birth (PTB; birth <37 completed weeks of gestation) and synthesise currently available evidence using meta-analysis.Methods:Spontaneous PTB cases and controls were selected from an existing cohort. Candidate SNPs were taken from an existing genotype panel. A systematic review was conducted for each SNP in the panel to determine suitability as a PTB candidate. Those with significant associations previously reported in Caucasians were selected for replication. Candidate SNPs were already genotyped in cases and controls and clinical data accessed from state perinatal and cerebral palsy databases. Association analysis was conducted between each SNP and PTB and meta-analysis conducted if there were ≥three studies in the literature. Maternal and fetal SNPs were considered as separate candidates.Results:A cohort of 170 cases and 583 controls was formed. Eight SNPs from the original panel of genotyped SNPs were selected as PTB candidates and replication based on systematic literature review results. In our cohort, fetal Factor V Leiden (FVL) was significantly associated with PTB (OR 2.6, 95% CI 1.31-5.17) and meta-analysis confirmed this association (OR 2.71, 95% CI 1.15-6.4).Conclusion:Replication and meta-analysis support an increased risk of PTB in Caucasians with the fetal FVL mutation.Pediatric Research (2013); doi:10.1038/pr.2013.117.
Michael E O'Callaghan; Alastair H Maclennan; Gai L McMichael; Eric A Haan; Gustaaf A Dekker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-08
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia.
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