Document Detail


Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level functions.
MedLine Citation:
PMID:  6511674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rate and phase of auditory-nerve response to tone bursts were studied as a function of stimulus level in normal and acoustically traumatized animals. The rate- and phase-level functions of normal auditory-nerve fibers are often separable into a low-intensity component (component I) and high-intensity component (component II), as defined by a dip in the rate function and a simultaneous abrupt shift in the phase function at stimulus levels near 90 dB SPL [10,12,9]. Baseline data are established by defining the relation between stimulus frequency and the characteristic frequency and spontaneous discharge rate of a fiber normally required for the appearance of these two components in the response. Abnormalities of the level functions are shown to occur in acoustically traumatized ears. Noise-induced threshold shift is often characterized by selective attenuation of component I. In some instances, it appears that component I has been eliminated, leaving a response which is identical in threshold, phase and maximum discharge rate to a normal component II. Results of single-unit labeling in such a case suggest that the selective attenuation of component I is associated with selective loss of the tallest row of stereocilia on the inner hair cells (IHCs). It is suggested that component I is normally generated through an interaction between the outer hair cells and the tall row of IHC stereocilia, while component II requires only the shorter row of IHC stereocilia.
Authors:
M C Liberman; N Y Kiang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  16     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-31     Completed Date:  1985-01-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-90     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Cilia / physiology
Cochlear Microphonic Potentials
Hair Cells, Auditory / physiopathology*
Hair Cells, Auditory, Inner / physiopathology
Hearing Loss, Noise-Induced / physiopathology*
Loudness Perception / physiology*
Nerve Fibers / physiology
Pitch Perception / physiology*
Vestibulocochlear Nerve / physiopathology*
Grant Support
ID/Acronym/Agency:
R01 NS01344/NS/NINDS NIH HHS; T32 MH14275/MH/NIMH NIH HHS; TO1 MH07084/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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