| Single-nephron adaptations to partial renal ablation in cats. | |
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MedLine Citation:
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PMID: 7503284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate remnant nephron hyperfiltration, cats underwent sham surgery (group 1, n = 6) or three-fourths nephrectomy (group 2, n = 6). Four to six weeks later, micropuncture studies demonstrated increases (P < 0.01) of single-nephron glomerular filtration rate (SNGFR) in group 2 (28.1 +/- 2.8 vs. 56.0 +/- 5.9 nl/min). In group 2 the mean estimated glomerular capillary pressure of 74.0 +/- 1.7 mmHg exceeded (P < 0.01) the value for group 1 (62.6 +/- 1.4 mmHg). The mean effective filtration pressure (EFPm) for group 2 (28.7 +/- 3.1 mmHg) was greater (P < 0.05) than that in group 1 (20.8 +/- 1.9 mmHg). Similarly, the mean ultrafiltration coefficient (Kf) in group 2 of 2.03 +/- 0.24 nl.min-1.mmHg-1 exceeded (P < 0.05) the corresponding value for group 1 of 1.35 +/- 0.06 nl.min-1.mmHg-1. Morphological studies demonstrated glomerular enlargement and mesangial matrix expansion in group 2 (P < 0.05). Proteinuria, as assessed by the urine protein-to-creatinine ratio, was increased (P < 0.05) after partial renal ablation. These results demonstrate that increases in SNGFR in feline remnant nephrons occur in association with glomerular hypertension, glomerular hypertrophy, expansion of mesangial matrix, and proteinuria, and furthermore, that the observed increases in SNGFR are attributable to an augmentation of EFPm and Kf. |
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Authors:
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S A Brown; C A Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-01-17 Completed Date: 1996-01-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1002-8 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Cats Female Glomerular Filtration Rate Hypertrophy Kidney Glomerulus / pathology, physiopathology Male Nephrectomy* Nephrons / physiopathology* Punctures Renal Circulation |
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