| Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: a systematic review of the literature. | |
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MedLine Citation:
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PMID: 15281996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of the current review was to determine if single versus two or more embryos, or double versus three or more embryos, transferred to the woman of a subfertile couple at in vitro fertilisation (IVF) maximises the likelihood of pregnancy, while minimising the likelihood of multiple pregnancy and adverse sequelae. METHODS: Studies were identified that reported maternal, infant and cost outcomes following embryo transfer at IVF. RESULTS: Three randomised trials and 17 cohort studies were included. From two randomised trials, single embryo transfer was found to result in decreased incidence of clinical pregnancy, multiple pregnancy and low birthweight. In the cohort studies for single embryo transfer compared with transfer of two or more embryos the incidence of live birth and singleton pregnancies was unchanged, and the incidence of multiple pregnancies and low birthweight was reduced. For double embryo transfer compared with the transfer of three or more embryos, the incidence of clinical pregnancy, live birth, preterm birth and low birthweight babies was reduced. CONCLUSIONS: Information on neonatal and maternal outcomes following transfer of different numbers of embryos is limited. Transfer of one embryo does not alter the likelihood of a singleton pregnancy or birth when compared to transfer of two or more embryos. Transfer of one or two embryos decreases the risk of a multiple pregnancy, preterm birth and low birthweight. Further large, well-designed randomised trials are required to provide maternal and neonatal outcomes of relevance to a couple undergoing IVF. |
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Authors:
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Marianna R Dare; Caroline A Crowther; Jodie M Dodd; Robert J Norman |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Review |
Journal Detail:
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Title: The Australian & New Zealand journal of obstetrics & gynaecology Volume: 44 ISSN: 0004-8666 ISO Abbreviation: Aust N Z J Obstet Gynaecol Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-07-29 Completed Date: 2005-04-18 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0001027 Medline TA: Aust N Z J Obstet Gynaecol Country: Australia |
Other Details:
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Languages: eng Pagination: 283-91 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Adelaide, Women's and Children's Hospital, North Adelaide, South Australia, Australia. marianna.dare@student.adelaide.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Australia Cohort Studies Embryo Transfer* Female Fertilization in Vitro* Humans New Zealand Pregnancy Pregnancy Outcome* Pregnancy, Multiple* Randomized Controlled Trials as Topic Risk Factors Twins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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