| Single-molecule fluorescence methods for the study of nucleic acids. | |
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MedLine Citation:
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PMID: 11406376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Single-molecule fluorescence methods and biomechanical tools provide exciting new opportunities to probe biochemical processes in unprecedented detail. The detection and spectroscopy of single fluorophores have recently been used to observe conformational changes and biochemical events involving nucleic acids. A number of fluorescence observables, including localization, quenching, polarization response and fluorescence resonance energy transfer, have been utilized. An exciting new opportunity of combining fluorescence methods and biomechanical tools to study the structural changes and functions of enzymes that participate in nucleic acid metabolism has also arisen. |
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Authors:
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T Ha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in structural biology Volume: 11 ISSN: 0959-440X ISO Abbreviation: Curr. Opin. Struct. Biol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-06-14 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107784 Medline TA: Curr Opin Struct Biol Country: England |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: IM |
Affiliation:
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Department of Physics and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. tjha@uiuc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biochemistry
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methods* DNA / chemistry Fluorescence Fluorescent Dyes / chemistry Nucleic Acids / chemistry* RNA / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Nucleic Acids; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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