| Single-molecule and bulk approaches to the DnaB replication fork helicase. | |
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MedLine Citation:
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PMID: 23276919 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Motor proteins are enzymes that accomplish mechanical work in a wide variety of biological processes. In this review we focus on bulk and single molecule methods to study how motor proteins function. We discuss in detail the analysis of the motor protein DnaB, a hexameric helicase that unwinds DNA at a replication fork in Gram-negative bacteria. Bulk and single-molecule studies have complemented one another to arrive at a comprehensive mechanistic view of how DnaB unwinds double-stranded DNA. |
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Authors:
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Daniel Lee Kaplan; Omar A Saleh; Noah Ribeck |
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Publication Detail:
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Type: Journal Article Date: 2013-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 18 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2013 |
Date Detail:
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Created Date: 2013-01-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 224-40 Citation Subset: IM |
Affiliation:
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Vanderbilt University, VU Station B, Box 35-1634, Department of Biological Sciences, Nashville, TN 37235. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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