Document Detail


Single measurements of C-reactive protein and disease activity scores are not predictors of carotid atherosclerosis in rheumatoid arthritis patients.
MedLine Citation:
PMID:  19449480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although inflammation has a defined role in the pathogenesis of atherosclerosis, the link between rheumatoid arthritis (RA) parameters of disease activity and atherosclerotic findings are not defined. OBJECTIVE: To investigate the association between subclinical carotid atherosclerosis and clinical/laboratorial parameters of RA systemic inflammatory activity. METHODS: Seventy-one RA patients were consecutively selected and compared to 53 healthy controls. Smoking, diabetes and hypertension were excluded, as well as the use of statins or fibrates. B-mode carotid ultrasound was performed in all subjects. CRP, ESR and fibrinogen were determined in both groups. Clinical assessment of RA activity included DAS 28 and SDAI. Correlation between plaques and intima-media thickness (IMT) of common carotid arteries and inflammatory parameters was evaluated. RESULTS: Carotid plaques were more prevalent in RA patients than in controls (14.1% vs. 1.9 %, p=0.02) and marginally increased IMT was observed (0.72 +/- 0.17 vs. 0.67 +/- 0.15 mm, p=0.07). RA patients with plaques had older age (p=0.001) and increased IMT (p<0.001), but low SDAI (p=0.025) compared to those without plaques. RA patients with plaques had also longer disease duration, although this difference did not reach statistical significance (p=0.06). No significant correlations were found between IMT and ESR (p=0.80), CRP (p=0.75), fibrinogen (p=0.94), HAQ (p=0.89) and DAS 28 (p=0.13). CONCLUSIONS: Carotid atherosclerosis is more frequently detected in RA but its prevalence was not correlated with isolated inflammatory markers measurement or noncumulative activity scores. These findings reinforce the need to evaluate subclinical atherosclerosis in RA patients, and to find predictors of atherosclerotic lesions.
Authors:
Ivânio Alves Pereira; Ieda M M Laurindo; Adriana F Zimmermann; Gláucio R Werner Castro; Filipe Mello; Eduardo Ferreira Borba
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta reumatológica portuguesa     Volume:  34     ISSN:  0303-464X     ISO Abbreviation:  Acta Reumatol Port     Publication Date:    2009 Jan-Mar
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0431702     Medline TA:  Acta Reumatol Port     Country:  Portugal    
Other Details:
Languages:  eng     Pagination:  58-64     Citation Subset:  IM    
Affiliation:
Rheumatology Division, University of Santa Catarina, Santa Catarina - Brazil. ivaniop@matrix.com.br
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Rheumatoid / complications*
C-Reactive Protein / analysis*
Carotid Artery Diseases / blood*,  etiology*
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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