| Single i.v. bolus dose of ondansetron in the prevention of postoperative nausea and emesis. | |
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MedLine Citation:
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PMID: 9526603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this placebo controlled, double blind multicentre study, the efficacy and safety of a single i.v. bolus dose of ondansetron 4 mg were evaluated in the prevention of postoperative nausea and vomiting (PONV), which remains one of the most unpleasant side effects experienced by patients postoperatively. The study population included patients having general anesthesia and undergoing major gynecological or elective abdominal surgery by laparoscopy. Thirty three percent of placebo-treated patients had at least one emetic episode over 24 hrs compared with 21% in the ondansetron group (p = 0.03). Forty two percent of placebo-treated patients experienced nausea in the 24 hours post-recovery period, compared to 27% of patients treated with ondansetron 4 mg (p = 0.01). Several factors appeared to be associated with an increased risk of developing PONV, namely gender (female), type of surgery (gynecological), experience of previous PONV and duration of anesthesia; the use of propofol was not a significant factor. Ondansetron was well tolerated, with no side effect being reported as a significant problem. |
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Authors:
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P Moens; M Levarlet; P Hendrickx; E De Guchteneere |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Acta anaesthesiologica Belgica Volume: 48 ISSN: 0001-5164 ISO Abbreviation: Acta Anaesthesiol Belg Publication Date: 1997 |
Date Detail:
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Created Date: 1998-04-24 Completed Date: 1998-04-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421022 Medline TA: Acta Anaesthesiol Belg Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: IM |
Affiliation:
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Cliniques Universitaires de Bruxelles, Hôpital Erasme. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antiemetics / administration & dosage, adverse effects, pharmacology* Double-Blind Method Female Humans Injections, Intravenous Laparoscopy Male Middle Aged Nausea / chemically induced, prevention & control* Ondansetron / administration & dosage, adverse effects, pharmacology* Postoperative Complications / chemically induced, prevention & control* Risk Factors Vomiting / chemically induced, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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