Document Detail

Single intra-arterial injection of mesenchymal stromal cells for treatment of steroid-refractory acute graft-versus-host disease: a pilot study.
MedLine Citation:
PMID:  19961282     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AIMS: Cell therapy with mesenchymal stromal cells (MSC) has been reported recently as a promising treatment for severe acute graft-versus-host disease (GvHD). METHODS: We designed a pilot study to treat severe hepatic or gut GvHD using MSC derived from only the donor and cultured without bovine serum. Because the number of cultured MSC is smaller using this method, we planned to treat patients by intra-arterial regional administration directly to the target organs. RESULTS: Three patients were enrolled, and the MSC could be expanded using donor serum. There were no obvious side-effects immediately after arterial injection. The maximum response was partial in one of three patients and did not continue for more than 2 months. Idiopathic pneumonia syndrome developed in two of the three patients. CONCLUSIONS: A single local arterial MSC injection was unable to save these patients' lives and so might not be more effective than multiple systemic intravenous MSC injection. Further clinical research and additional strategies are required to develop appropriate methods for using MSC to achieve extended remission of GvHD.
Nobuyoshi Arima; Fumiaki Nakamura; Akiko Fukunaga; Hirokazu Hirata; Hiroko Machida; Shigene Kouno; Hajime Ohgushi
Publication Detail:
Type:  Case Reports; Clinical Trial; Letter    
Journal Detail:
Title:  Cytotherapy     Volume:  12     ISSN:  1477-2566     ISO Abbreviation:  Cytotherapy     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-03     Completed Date:  2010-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100895309     Medline TA:  Cytotherapy     Country:  England    
Other Details:
Languages:  eng     Pagination:  265-8     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Drug Resistance* / drug effects
Fatal Outcome
Graft vs Host Disease / prevention & control,  therapy*
Injections, Intra-Arterial
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / cytology*,  drug effects*
Middle Aged
Pilot Projects
Radiography, Thoracic
Steroids / pharmacology*,  therapeutic use
Stromal Cells / cytology,  transplantation*
Tomography, X-Ray Computed
Reg. No./Substance:

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