| Single injection of methotrexate for treatment of ectopic pregnancies. | |
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MedLine Citation:
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PMID: 7802072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to evaluate the efficacy of single-dose methotrexate as a treatment option for ectopic pregnancies. STUDY DESIGN: Patients were recruited from a tertiary teaching hospital setting. They had (1) a gestational sac < 3.5 cm, (2) no fetal cardiac activity, and (3) no significant pelvic pain or signs consistent with hemoperitoneum. Patients excluded were those who did not desire future fertility or who had evidence of renal or liver disease. Sixty-one patients meeting these criteria were selected and treated with a single intramuscular injection of methotrexate at a dosage of 50 mg/m2. RESULTS: Of the 61 patients treated, 16 required a second injection and nine required surgical intervention. Fifty-two (85%) were successfully treated as outpatients with methotrexate alone. CONCLUSION: Nonsurgical treatment of ectopic pregnancies with single-dose methotrexate is an option for some patients, but more studies are needed to establish the safety, efficacy, and effect on fertility. |
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Authors:
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M A Henry; W L Gentry |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 171 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-23 Completed Date: 1995-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1584-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Methodist Hospital of Indiana, Inc., Indianapolis 46206-1367. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Gonadotropin
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blood Drug Administration Schedule Female Humans Injections, Intramuscular Methotrexate / administration & dosage*, therapeutic use Ovarian Follicle / surgery Ovariectomy Pregnancy Pregnancy, Ectopic / drug therapy*, surgery Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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