Document Detail

Single injection of methotrexate for treatment of ectopic pregnancies.
MedLine Citation:
PMID:  7802072     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to evaluate the efficacy of single-dose methotrexate as a treatment option for ectopic pregnancies. STUDY DESIGN: Patients were recruited from a tertiary teaching hospital setting. They had (1) a gestational sac < 3.5 cm, (2) no fetal cardiac activity, and (3) no significant pelvic pain or signs consistent with hemoperitoneum. Patients excluded were those who did not desire future fertility or who had evidence of renal or liver disease. Sixty-one patients meeting these criteria were selected and treated with a single intramuscular injection of methotrexate at a dosage of 50 mg/m2. RESULTS: Of the 61 patients treated, 16 required a second injection and nine required surgical intervention. Fifty-two (85%) were successfully treated as outpatients with methotrexate alone. CONCLUSION: Nonsurgical treatment of ectopic pregnancies with single-dose methotrexate is an option for some patients, but more studies are needed to establish the safety, efficacy, and effect on fertility.
M A Henry; W L Gentry
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  171     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-23     Completed Date:  1995-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1584-7     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Methodist Hospital of Indiana, Inc., Indianapolis 46206-1367.
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MeSH Terms
Chorionic Gonadotropin / blood
Drug Administration Schedule
Injections, Intramuscular
Methotrexate / administration & dosage*,  therapeutic use
Ovarian Follicle / surgery
Pregnancy, Ectopic / drug therapy*,  surgery
Prospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin; 59-05-2/Methotrexate

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