Document Detail

Single fraction spine radiosurgery for myeloma epidural spinal cord compression.
MedLine Citation:
PMID:  19827269     Owner:  NLM     Status:  MEDLINE    
Radiosurgery delivers highly focused radiation beams to the defined target with high precision and accuracy. It has been demonstrated that spine radiosurgery can be safely used for treatment of spine metastasis with rapid and durable pain control, but without detrimental effects to the spinal cord. This study was carried out to determine the role of single fraction radiosurgery for epidural spinal cord compression due to multiple myeloma. A total of 31 lesions in 24 patients with multiple myeloma, who presented with epidural spinal cord compression, were treated with spine radiosurgery. Single fraction radiation dose of 10-18 Gy (median of 16 Gy) was administered to the involved spine including the epidural or paraspinal tumor. Patients were followed up with clinical exams and imaging studies. Median follow-up was 11.2 months (range 1-55). Primary endpoints of this study were pain control, neurological improvement, and radiographic tumor control. Overall pain control rate was 86%; complete relief in 54%, and partial relief in 32% of the patients. Seven patients presented with neurological deficits. Five patients neurologically improved or became normal after radiosurgery. Complete radiographic response of the epidural tumor was noted in 81% at 3 months after radiosurgery. During the follow-up time, there was no radiographic or neurological progression at the treated spine. The treatment was non-invasive and well tolerated. Single fraction radiosurgery achieved an excellent clinical and radiographic response of myeloma epidural spinal cord compression. Radiosurgery can be a viable treatment option for myeloma epidural compression.
Ryan Jin; Jack Rock; Jian-Yue Jin; Nalini Janakiraman; Jae Ho Kim; Benjamin Movsas; Samuel Ryu
Related Documents :
12376769 - Effect of partial targeted n-butyl-cyano-acrylate embolization in brain avm.
23910089 - Magnetic resonance imaging-guided cryoablation of recurrent prostate cancer after radic...
20305489 - Exacerbation of perihematomal edema and sterile meningitis with intraventricular admini...
15964709 - Cognitive function after radiotherapy for supratentorial low-grade glioma: a north cent...
99379 - Conservative surgical treatment of mandibular ameloblastomas.
2674079 - Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard...
24199469 - Evaluation of surgical treatment of developmental dysplasia of hip for avascular necros...
23357349 - Influence of preoperative and postoperative pelvic floor muscle training (pfmt) compare...
22525939 - Effect of different statistical methods on union or time to union in a published study ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of experimental therapeutics & oncology     Volume:  8     ISSN:  1359-4117     ISO Abbreviation:  J. Exp. Ther. Oncol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-15     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604933     Medline TA:  J Exp Ther Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Epidural Space
Middle Aged
Multiple Myeloma / complications*
Radiosurgery / adverse effects,  methods*
Spinal Cord Compression / surgery*
Spine / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells.
Next Document:  Alleviating effect of active hexose correlated compound (AHCC) for anticancer drug-induced side effe...