Document Detail

Single-fibre and whole-nerve responses to clicks as a function of sound intensity in the guinea pig.
MedLine Citation:
PMID:  1618706     Owner:  NLM     Status:  MEDLINE    
This paper describes a study of the intensity dependence of click-evoked responses of auditory-nerve fibres in relation to the simultaneously recorded compound action potential (CAP). Condensation and rarefaction clicks were presented to normal hearing guinea pigs over an intensity range of 60 dB. The recorded poststimulus time histograms (PSTHs) were characterized by the latency (tp), amplitude (Ap) and synchronization (Sp) of their dominant peak, parameters that are particularly important for the understanding of the CAP. For all fibres tp decreased monotonically with increasing intensity, in a continuous way for fibres with high characteristic frequency (CF greater than 3 kHz), and in discrete steps of one CF-cycle for low-CF (CF less than or equal to 3 kHz) fibres. An additional analysis of PSTH envelopes revealed that average latency shifts with intensity are similar for all CFs above 2 kHz. For all fibres Ap increased monotonically with intensity; the increase was stronger and maximum values were larger for low-CF than for high-CF fibres. A schematic model PSTH was then formulated on the basis of the experimental data. A sum of these model PSTHs from a hypothesized fibre population was convolved with an elemental unit response (Versnel et al., 1992) in order to simulate the compound action potential. Synthesized CAPs agreed with experimental CAPs in their main aspects.
H Versnel; R Schoonhoven; V F Prijs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  59     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-31     Completed Date:  1992-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  138-56     Citation Subset:  IM    
ENT Department, University Hospital, Leiden, The Netherlands.
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MeSH Terms
Acoustic Stimulation
Action Potentials / physiology
Auditory Threshold
Evoked Potentials, Auditory / physiology*
Guinea Pigs
Nerve Fibers / physiology*
Vestibulocochlear Nerve / physiology*

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