Document Detail

Single fiber EMG and repetitive stimulation of the same muscle in myasthenia gravis.
MedLine Citation:
PMID:  8114786     Owner:  NLM     Status:  MEDLINE    
We performed RNS and SFEMG studies of the same muscle in 46 patients with myasthenia gravis. Maximum decrement to 3-5-Hz stimulation before and after maximum voluntary exercise, percentage of action potential pairs with increased jitter and blocking, and mean MCD in each study were compared. A significant decrement (> 10% decrease in CMAP area or amplitude between the first and fourth response) was never found without increased jitter and impulse blocking on SFEMG. Increased jitter, blocking, and mean MCD were each correlated with maximum decrement (r > 0.61, P < 0.0001). We conclude that decrement to RNS and impulse blocking on SFEMG result from the same physiologic phenomenon, and that SFEMG is more sensitive at detecting disordered neuromuscular transmission given its ability to detect impulse blocking at levels below the resolution of RNS and increased neuromuscular jitter when there is not blocking.
J M Gilchrist; J M Massey; D B Sanders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  17     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-29     Completed Date:  1994-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Department of Neurology, Rhode Island Hospital, Brown University, Providence.
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MeSH Terms
Electric Stimulation / methods
Middle Aged
Muscles / physiopathology*
Myasthenia Gravis / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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