Document Detail

Single fiber EMG in the frontalis muscle in ocular myasthenia: specificity and sensitivity.
MedLine Citation:
PMID:  1557090     Owner:  NLM     Status:  MEDLINE    
Patients (n = 41) with isolated weakness of the eyelids or extraocular muscles, who had been referred for single fiber electromyography (SFEMG), were followed up after 4 to 24 months, At follow-up the patients were classified as "definite ocular myasthenia gravis" (MG), "definite other diagnosis," or "no definite diagnosis" on the basis of the completed investigations and subsequent course. The original SFEMG findings in the frontalis muscle were then reviewed. The specificity and sensitivity of SFEMG for "definite ocular MG" could be maximized by using as criteria for abnormality greater than 8/20 pairs with jitter greater than 45 microseconds, or a mean jitter of 20 pairs of greater than 50 microseconds. Patients with abnormal SFEMG according to these criteria have MG, and are likely to require treatment in the immediate future. Patients who have normal SFEMG according to these criteria (and no other demonstrated disorder) may have MG, but it is so mild that they are unlikely to require treatment. Two patients whose final diagnosis was progressive external ophthalmoplegia had normal SFEMG according to these criteria.
R Rouseev; P Ashby; A Basinski; J A Sharpe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  15     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-07     Completed Date:  1992-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  399-403     Citation Subset:  IM    
Division of Neurology, Toronto Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Blepharoptosis / etiology
Diplopia / etiology
Electromyography / methods
Middle Aged
Myasthenia Gravis / complications,  diagnosis*
Oculomotor Muscles / physiopathology*
Sensitivity and Specificity

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