| Single- or double-blind treatment With Balsamodendron mukul and nifedipine in hypertensive patients. | |
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MedLine Citation:
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PMID: 16088297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assessed and compared the effects of Balsamodendron mukul (an extract of the gum of a small tree) and nifedipine (a calcium-channel-blocking reference drug) on blood pressure, lipids, lipoproteins, and phospholipids in randomly selected patients with essential hypertension. Fifty-seven newly diagnosed hypertensive patients were randomly divided into three groups. They received either single-blind B. mukul (1.5 g/d) or single-blind nifedipine (10 mg/d) double-blind therapy with nifedipine (10 mg/d) and B. mukul (1.5 g/d) for 6 weeks. These groups were compared with control subjects. On treatment with B. mukul, levels of systolic blood pressure, diastolic blood pressure, plasma total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, free fatty acids, and phospholipid levels were significantly reduced, and high-density lipoprotein cholesterol levels were significantly elevated, as compared with untreated hypertensive patients. Combined therapy with B. mukul and nifedipine was more beneficial than the treatment with B. mukul alone. Our study suggests that B. mukul may be an effective antihypertensive and hypolipidemic agent. |
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Authors:
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Jayabal Panneerselvam; Ganapathy Sambandam; Namasivayam Nalini |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 7 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-09 Completed Date: 2005-11-08 Revised Date: 2005-12-27 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 340-5 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Annamalai University, Annamalainagar, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / drug effects Calcium Channel Blockers / therapeutic use* Double-Blind Method Drug Therapy, Combination Female Humans Hypertension / blood, drug therapy*, physiopathology Lipoproteins / blood Male Middle Aged Nifedipine / therapeutic use* Plant Extracts / therapeutic use* Single-Blind Method Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Lipoproteins; 0/Plant Extracts; 0/Triglycerides; 21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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