Document Detail


Single doses of ritodrine delay orocaecal transit in patients with irritable bowel syndrome.
MedLine Citation:
PMID:  2310659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lactulose hydrogen breath test was used to assess the effect of a single dose of the beta 2-adrenoceptor agonist ritodrine on orocaecal transit time in 11 patients (three men) with irritable bowel syndrome. Transit time (median values, range) was significantly longer (P less than 0.01) after ritodrine than after placebo (120, 50-200 vs 75, 40-100 min). Median heart rate was similar before treatments whereas the maximal increase in heart rate was significantly greater (P less than 0.01) after ritodrine than after placebo.
Authors:
G Basilisco; M G Camboni; A Bozzani; M Molgora; P A Bianchi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  29     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  IM    
Affiliation:
Cattedra di Patologia Medica III, Università degli Studi di Milano, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Breath Tests
Colonic Diseases, Functional / drug therapy*,  physiopathology
Double-Blind Method
Female
Gastrointestinal Transit / drug effects*
Heart Rate / drug effects
Humans
Lactulose / analysis
Male
Middle Aged
Random Allocation
Ritodrine / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
26652-09-5/Ritodrine; 4618-18-2/Lactulose
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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