Document Detail

Single-dose treatment of bacteriuria in pregnancy.
MedLine Citation:
PMID:  3552699     Owner:  NLM     Status:  MEDLINE    
Comparison of the results of single-dose treatment of urinary tract infection in women is confused by differences between published series in the duration of follow-up and in the diagnosis of infection. Pregnancy allows prolonged follow-up in a motivated population, but increases the possibility of false positive diagnosis of infection from midstream urines due to increased vulvovaginal contamination. Suprapubic aspiration (SPA) is safe in pregnancy and accurately confirms the presence or absence of bacteria in the bladder urine. Bacteriuria was diagnosed by SPA in 86 pregnant women. Thirty-seven of these were treated with a single dose of 3 g cephalexin and 49 with 3 days of cephalexin 1 g or of a combined preparation of pivmecillinam-pivampicillin. Both single-dose and 3-day treatments prevented further bacteriuria in 65% of the patients for the remainder of their pregnancies. This is similar to the results achieved with 10-day treatment. If extended trials confirm that single-dose treatment is as effective as conventional treatment with the same drug, then single-dose treatment has the advantages in pregnancy of minimal medication, good patient compliance and lack of side-effects.
I R McFadyen; M Campbell-Brown; M Stephenson; D V Seal
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European urology     Volume:  13 Suppl 1     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-05-26     Completed Date:  1987-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  22-5     Citation Subset:  IM    
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MeSH Terms
Amdinocillin / therapeutic use*
Amdinocillin Pivoxil / administration & dosage,  therapeutic use*
Ampicillin / analogs & derivatives*
Bacteriuria / drug therapy*
Cephalexin / administration & dosage,  therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Drug Combinations
Escherichia coli Infections / drug therapy*
Pivampicillin / administration & dosage,  therapeutic use*
Pregnancy Complications, Infectious / drug therapy*
Random Allocation
Reg. No./Substance:
0/Drug Combinations; 15686-71-2/Cephalexin; 32886-97-8/Amdinocillin Pivoxil; 32887-01-7/Amdinocillin; 33817-20-8/Pivampicillin; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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