Document Detail

Single-dose tioconazole compared with 3-day clotrimazole treatment in vulvovaginal candidiasis.
MedLine Citation:
PMID:  3524439     Owner:  NLM     Status:  MEDLINE    
A total of 80 patients were equally randomized to receive a single dose of 6.5% tioconazole ointment or a 3-day course of 100-mg clotrimazole vaginal tablets for the treatment of vulvovaginal candidiasis. Of the 32 evaluable patients treated with tioconazole, 27 (84%) remained asymptomatic 4 weeks posttreatment, compared with 28 of 33 patients (85%) treated with clotrimazole. A total of 34 patients in each group could be evaluated for mycological response based on culture results 1 and 4 weeks after treatment. Twenty patients (59%) who received tioconazole and twenty-one patients (62%) who received clotrimazole remained culture negative 4 weeks after therapy. Of 40 patients who received tioconazole, 12 (30%) experienced local irritation or itching, compared with 2 of 40 patients (5%) treated with clotrimazole (P less than 0.01). Single-dose tioconazole ointment was as effective as a 3-day course of clotrimazole tablets, but significantly more patients in the tioconazole-treated group experienced local side effects.
G E Stein; D Gurwith; N Mummaw; M Gurwith
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  29     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-08-15     Completed Date:  1986-08-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  969-71     Citation Subset:  IM    
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MeSH Terms
Antifungal Agents / administration & dosage*,  adverse effects,  therapeutic use
Candidiasis, Vulvovaginal / drug therapy*
Clinical Trials as Topic
Clotrimazole / administration & dosage*,  adverse effects,  therapeutic use
Imidazoles / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Random Allocation
Reg. No./Substance:
0/Antifungal Agents; 0/Imidazoles; 23593-75-1/Clotrimazole; 65899-73-2/tioconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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