Document Detail


Single-dose thymoglobulin induction in living-donor renal transplantation.
MedLine Citation:
PMID:  21716186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The use of Thymoglobulin induction therapy in living-donor renal transplantation remains controversial. We aimed to evaluate outcomes in living-related donor (LRD) and living unrelated donor (LURD) renal transplants with Thymoglobulin induction.
MATERIAL/METHODS: We retrospectively analysed the outcome of all Thymoglobulin induced living-donor renal transplants performed at our centre from 2002 to 2010.
RESULTS: We reviewed 100 living-donor renal transplants (LRD=60; LURD=40) who received thymoglobulin induction (single dose, 1.5 mg/kg bodyweight) with a mean follow-up of 52.6 ± 31.9 months. Although baseline characteristics of the LRD and LURD groups were similar, differences were noted for recipient age, gender, and HLA-matching. Overall, the estimated 5-year patient survival was 92% and graft survival, 83%. The 1- and 5-year patient survival rates were 97.4% and 90.7% for LRD and 98.3% and 92.2% for LURD (P=0.79), respectively. Cumulative graft survival (LRD vs. LURD) rates were 93% vs. 95% after 1 year and 80% vs. 88% after 5 years (P=0.53). Kidney graft function was comparable for both the groups. Acute rejection was observed in 17% LRD and 35% LURD patients (P=0.035). Further, 10% of the patients experienced delayed graft function (LRD 11% vs. LURD 8%; P=NS). Rates of cytomegalovirus (CMV) infection (10%), polyomavirus infection (5%), malignancy (4%), and lymphoproliferative disorder (0%) were low, with no differences between the 2 groups.
CONCLUSIONS: Single-dose thymoglobulin induction in living-donor renal transplantation was associated with high patient and graft survival without increasing the risk of infections or malignancy and without significant differences between LRD and LURD patients.
Authors:
Peter Schenker; Arzu Ozturk; Oliver Vonend; Bernd Krüger; Martin Jazra; Andreas Wunsch; Bernhard Krämer; Richard Viebahn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of transplantation : quarterly of the Polish Transplantation Society     Volume:  16     ISSN:  2329-0358     ISO Abbreviation:  Ann. Transplant.     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-06-30     Completed Date:  2011-10-31     Revised Date:  2013-06-17    
Medline Journal Info:
Nlm Unique ID:  9802544     Medline TA:  Ann Transplant     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  50-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, Knappschafts-Hospital, Ruhr-University Bochum, Germany. peter.schenker@rub.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Antilymphocyte Serum*
Graft Survival*
Humans
Immunosuppression / methods*
Kidney Failure, Chronic / therapy*
Kidney Transplantation / methods*,  mortality
Living Donors*
Middle Aged
Prospective Studies
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum; 0/thymoglobulin

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