Document Detail

Single-dose systemic methotrexate for the treatment of persistent ectopic pregnancy after conservative surgery.
MedLine Citation:
PMID:  8272308     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a single outpatient methotrexate injection successfully treats persistent ectopic pregnancy. METHODS: Nineteen consecutive patients with increasing beta-hCG titers after conservative surgery for ectopic pregnancy were treated with a single intramuscular methotrexate (50 mg/m2) injection. RESULTS: All 19 patients had resolution of their beta-hCG titers without subsequent surgery. Beta-hCG levels commonly increased during the first 3 days after treatment, but subsequently declined. Two patients required hospital admission for observation and analgesia. One of these two patients had probable self-limited intra-abdominal bleeding and required a blood transfusion. CONCLUSION: A single methotrexate injection is a safe and successful treatment for persistent ectopic pregnancy. Delayed hemorrhage may be a rare complication, and close surveillance is necessary.
D E Hoppe; B E Bekkar; C W Nager
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  83     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-01-28     Completed Date:  1994-01-28     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-4     Citation Subset:  AIM; IM    
Department of Reproductive Medicine, University of California, School of Medicine, San Diego.
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MeSH Terms
Chorionic Gonadotropin / blood
Methotrexate / administration & dosage*,  therapeutic use
Pregnancy, Ectopic / blood,  drug therapy*,  surgery
Treatment Failure
Reg. No./Substance:
0/Chorionic Gonadotropin; 59-05-2/Methotrexate

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