| Single dose of rasburicase for treatment of hyperuricemia in acute kidney injury: a report of 3 cases. | |
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MedLine Citation:
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PMID: 21368393 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Severe hyperuricemia accompanied by the other comorbidities such as anuria, fluid overload, calcium-phosphate imbalance, and/or tumor lysis syndrome is one of the indications for dialysis in the setting of acute kidney injury. Rasburicase is used in different clinical conditions such as tumor lysis syndrome and uric acid nephropathy. Among referred patients to our center from 2008 to 2010, there were 3 patients who had an indication for dialysis because of hyperuricemia. Contributing factors to the acute kidney injury were multi-organ dysfunction, rapidly progressive glomerulonephritis, and spontaneous tumor lysis syndrome. None of the patients showed any response to treatment with bicarbonate and hydration. After rasburicase administration, serum uric acid level declined, and urine output increased. Treatment with a single low dose of rasburicase would be effective to decrease the serum uric acid level and reverse kidney injury secondary to uric acid nephropathy. |
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Authors:
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Nakysa Hooman; Hasan Otukesh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Iranian journal of kidney diseases Volume: 5 ISSN: 1735-8582 ISO Abbreviation: Iran J Kidney Dis Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316967 Medline TA: Iran J Kidney Dis Country: Iran |
Other Details:
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Languages: eng Pagination: 130-2 Citation Subset: IM |
Affiliation:
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Department of Pediatric Nephrology, Ali-Asghar Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. nakih@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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