Document Detail


Single-dose pharmacokinetics of cefpirome in patients receiving hemodialysis and in patients treated by continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  8222482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cefpirome is eliminated primarily by renal excretion, compelling dosage reduction in kidney failure. We studied the elimination kinetics after intravenous administration of 1 gm cefpirome in patients undergoing hemodialysis (n = 9) and after intravenous (n = 6) or intraperitoneal administration (n = 6) of 1 gm cefpirome in subjects treated by continuous ambulatory peritoneal dialysis (CAPD). Four hours of hemodialysis removed 48% +/- 9% of the drug present in the body at the start of hemodialysis. Consequently, a supplementary dose equal to 50% of the daily dose recommended in end stage renal disease (ESRD) should be administered after each hemodialysis treatment. In patients receiving CAPD, therapeutic levels in both serum and dialysate were reached after intravenous and intraperitoneal administration. The bioavailability after intraperitoneal administration was 84%. After systemic administration, the elimination of cefpirome in the dialysate was negligible. Consequently, systemic dosage of cefpirome in patients receiving CAPD and in patients with ESRD should be identical.
Authors:
N Veys; N Lameire; V Malerczyk; K H Lehr; B Rosenkranz; S Ringoir
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  54     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-29     Completed Date:  1993-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  AIM; IM    
Affiliation:
Department of Nephrology, University of Gent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Availability
Cephalosporins / administration & dosage,  pharmacokinetics*
Female
Humans
Kidney Failure, Chronic / metabolism*,  therapy
Male
Middle Aged
Models, Biological
Peritoneal Dialysis, Continuous Ambulatory*
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Cephalosporins; 84957-29-9/cefpirome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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