Document Detail

Single-dose methotrexate: an expanded clinical trial.
MedLine Citation:
PMID:  8317518     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to report an expanded clinical trial with a nonlaparoscopic approach to ectopic pregnancy diagnosis combined with single-dose intramuscular methotrexate treatment. STUDY DESIGN: A prospective cohort of 120 women with an ectopic pregnancy < or = 3.5 cm in greatest dimension was enrolled. RESULTS: Patients had a mean age of 26.1 +/- 6.2 years, a mean gravidity of 3.2 +/- 1.6, and a mean parity of 0.97 +/- 1.0. The mean human chorionic gonadotropin titer before treatment initiation was 3950 +/- 1193 mIU/ml. Transvaginal ultrasonography visualized cardiac activity in 14 (11.7%) patients, with an ectopic mass visualized in 113 (94.2%). The mean time to resolution in the 113 (94.2%) subjects successfully treated was 35.5 +/- 11.8 days. Four (3.3%) patients required a second methotrexate dose on day 7. No biochemical or clinical side effects occurred. Posttreatment hysterosalpingograms demonstrated tubal patency on the ipsilateral side in 51 of 62 (82.3%) patients. Of those attempting pregnancy, 79.6% were pregnant, 87.2% intrauterine and 12.8% ectopic. The mean time to achieve pregnancy was 3.2 +/- 1.1 months. CONCLUSIONS: This regimen requires minimal laboratory follow-up and eliminates leukovorin recovery, making it the regimen of choice for medical treatment of unruptured ectopic pregnancy.
T G Stovall; F W Ling
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-28     Completed Date:  1993-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1759-62; discussion 1762-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Tennessee, Memphis.
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MeSH Terms
Chorionic Gonadotropin / blood
Injections, Intramuscular
Methotrexate / administration & dosage*,  therapeutic use
Pregnancy, Tubal / blood,  drug therapy*,  ultrasonography
Reg. No./Substance:
0/Chorionic Gonadotropin; 59-05-2/Methotrexate
Comment In:
Am J Obstet Gynecol. 1994 Jun;170(6):1840-1   [PMID:  8203452 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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