| Single-dose methotrexate: an expanded clinical trial. | |
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MedLine Citation:
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PMID: 8317518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Our purpose was to report an expanded clinical trial with a nonlaparoscopic approach to ectopic pregnancy diagnosis combined with single-dose intramuscular methotrexate treatment. STUDY DESIGN: A prospective cohort of 120 women with an ectopic pregnancy < or = 3.5 cm in greatest dimension was enrolled. RESULTS: Patients had a mean age of 26.1 +/- 6.2 years, a mean gravidity of 3.2 +/- 1.6, and a mean parity of 0.97 +/- 1.0. The mean human chorionic gonadotropin titer before treatment initiation was 3950 +/- 1193 mIU/ml. Transvaginal ultrasonography visualized cardiac activity in 14 (11.7%) patients, with an ectopic mass visualized in 113 (94.2%). The mean time to resolution in the 113 (94.2%) subjects successfully treated was 35.5 +/- 11.8 days. Four (3.3%) patients required a second methotrexate dose on day 7. No biochemical or clinical side effects occurred. Posttreatment hysterosalpingograms demonstrated tubal patency on the ipsilateral side in 51 of 62 (82.3%) patients. Of those attempting pregnancy, 79.6% were pregnant, 87.2% intrauterine and 12.8% ectopic. The mean time to achieve pregnancy was 3.2 +/- 1.1 months. CONCLUSIONS: This regimen requires minimal laboratory follow-up and eliminates leukovorin recovery, making it the regimen of choice for medical treatment of unruptured ectopic pregnancy. |
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Authors:
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T G Stovall; F W Ling |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 168 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-07-28 Completed Date: 1993-07-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1759-62; discussion 1762-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Tennessee, Memphis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chorionic Gonadotropin / blood Female Humans Injections, Intramuscular Methotrexate / administration & dosage*, therapeutic use Pregnancy Pregnancy, Tubal / blood, drug therapy*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 59-05-2/Methotrexate |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 1994 Jun;170(6):1840-1
[PMID:
8203452
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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