Document Detail

Single dose extra-amniotic prostaglandin gel for midtrimester termination of pregnancy.
MedLine Citation:
PMID:  6932206     Owner:  NLM     Status:  MEDLINE    
The efficacy of a single dose of prostaglandin F2 alpha gel instilled into the extra-amniotic space to induce termination of pregnancy in the second trimester has been assessed and compared with intra-amniotic prostaglandin F2 alpha and with an extra-amniotic infusion of prostaglandin F2 alpha combined with intravenous oxytocin. There was no significant difference between the methods in time taken to abortion, incidence of retained placenta, need for blood transfusion, or rate of sepsis. Single dose extra-amniotic prostaglandin gel is recommended as a safe, effective, and convenient method of midtrimester termination of pregnancy.
The efficacy of giving single-dose (40 mg) prostaglandin F2 alpha (PGF2a) in viscous gel instilled extraamniotically for pregnancy termination was compared with the use of intraamniotic injection of PGF2a and with extraamniotic infusion of PGF2a combined with intravenous oxytocin. Pregnancy induction occurred in second trimester patients. The 3 patient groups had no significant differences in age, gestation, or parity. There were no statistical differences in parameters measured, including time to abortion and side effects. Although more cases had aborted by 24 hours in the extramniotic PGF2a gel group, this was not statistically significant. Side effects encountered, but still not enough times to draw significant associations, were retention of placenta, gastrointestinal effects, need for blood transfusion, and sepsis. Because PGE2 is not available in Australia, these authors advocate the use of a single extraamniotic dose of PGF2a for pregnancy termination in the second trimester.
M A Quinn; P A Shekleton; R Wein; M Kloss
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  20     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  77-9     Citation Subset:  IM; J    
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MeSH Terms
Abortion, Induced / methods*
Oxytocin / pharmacology
Pregnancy Trimester, Second
Prostaglandins F / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Prostaglandins F; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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