Document Detail

Single-dose clavulanate-potentiated amoxycillin versus three-dose cefotaxime in the prevention of wound infection following elective cholecystectomy: a prospective randomized study.
MedLine Citation:
PMID:  3288525     Owner:  NLM     Status:  MEDLINE    
A prospective randomized study was carried out to evaluate the efficacy of clavulanate-potentiated amoxycillin with that of cefotaxime as prophylactic agents for the prevention of sepsis following elective cholecystectomy. One hundred patients were randomized into two treatment groups. In the first group, each patient received a single intravenous dose (1200 mg) of clavulanate-potentiated amoxycillin 2 h before surgery. In the second group, patients were given intravenous cefotaxime, in three doses (2 g each) during surgery, and 6 and 12 h after their operation. No case of serious post-operative sepsis occurred in either group. Superficial wound infection occurred in 2% of patients receiving a single pre-operative dose of clavulanate-potentiated amoxycillin and in 6% of those given cefotaxime according to the three-dose regimen.
M B el Mufti; A Glessa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  16     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-07-22     Completed Date:  1988-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
Department of General Surgery, 7th of April Hospital, Hawari, Benghazi, Socialist People's Libyan Arab Jamahiriya.
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MeSH Terms
Amoxicillin / administration & dosage,  pharmacology,  therapeutic use*
Cefotaxime / administration & dosage,  therapeutic use*
Cholecystectomy / adverse effects*
Clavulanic Acid
Clavulanic Acids / administration & dosage,  pharmacology,  therapeutic use*
Clinical Trials as Topic
Drug Synergism
Drug Therapy, Combination
Postoperative Care
Prospective Studies
Random Allocation
Surgical Wound Infection / etiology,  prevention & control*
Reg. No./Substance:
0/Clavulanic Acids; 26787-78-0/Amoxicillin; 58001-44-8/Clavulanic Acid; 63527-52-6/Cefotaxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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