Document Detail


Single-dose cefotetan vs. multiple-dose cefoxitin--antimicrobial prophylaxis in colorectal surgery. Results of a prospective, multicenter, randomized study.
MedLine Citation:
PMID:  2644108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This multicenter, prospective, randomized trial of short-term antimicrobial prophylaxis in colorectal surgery was designed to compare the efficacy of a single dose of cefotetan vs. multiple doses of cefoxitin. Of the 403 evaluable patients, 206 received cefoxitin (1 gm intravenously at the beginning of surgery and after 3, 6, and 12 hours, group A) and 197 cefotetan (2 gm intravenously at the beginning of surgery, group B). The two groups of patients were similar in respect to age, sex, obesity, preoperative weight loss, diabetes, type of disease, type, and mean duration of surgery. The abdominal wound infection rate was 11.2 percent in group A and 9.1 percent in group B (difference not significant). The number of patients with infections at nonsurgical sites (respiratory and urinary tract, phlebitis, and septicemia) was significantly greater in group A than in group B (17 vs. 9.1 percent, P less than .05). The mean postoperative hospital stay was similar in both the cefoxitin and cefotetan groups (15.1 vs. 15.9 days). Both regimens were inadequate in preventing infections in the presence of severe contamination of the operative field.
Authors:
P Periti; T Mazzei; F Tonelli
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  32     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-21     Completed Date:  1989-03-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Affiliation:
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cefotetan / administration & dosage*,  pharmacokinetics
Cefoxitin / administration & dosage*,  pharmacokinetics
Colon / surgery*
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Premedication*
Prospective Studies
Random Allocation
Rectum / surgery*
Surgical Wound Infection / prevention & control*
Chemical
Reg. No./Substance:
35607-66-0/Cefoxitin; 69712-56-7/Cefotetan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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