| Single-centre vs. population-based outcome data of extremely preterm infants at the limits of viability. | |
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MedLine Citation:
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PMID: 19575767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: In response to the disappointing outcome data of the population-based EPICure study published in 2000, we compared the outcome of infants 22 0/7 to 25 6/7 weeks of gestational age (GA) in a single tertiary care centre 2000-2004 with that of EPICure. METHODS: EPICure tools and definitions, including 30 months' Bayley Scales. RESULTS: Of 83 infants <26 weeks born alive, more were admitted to intensive care--82% vs. 68% (p < 0.0001)--and more infants survived to discharge (57% vs. 26%, p < 0.0001; 69% vs. 39%, p < 0.01, of those admitted to intensive care). More infants, as a percentage of live births, survived without severe (41%, 34/83 vs. 20%, 233/1185, p < 0.0001) or overall disability (22%, 18/83 vs. 13%, 155/1185, p = 0.03). However, at the border of viability--GA 23 and 24 weeks--the rate of infants surviving without overall disability was not significantly higher (13%, 6/45 vs. 9%, 56/623). CONCLUSION: In infants <26 weeks of GA, increased rates of survival and survival without disability were observed in a single-centre inborn cohort born 5-8 years later than the EPICure cohort. This did not translate into increased survival without overall disability in infants of 23-24 weeks of GA. |
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Authors:
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Patrizia Kutz; Sandra Horsch; Lisa Kühn; Claudia Roll |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-07-03 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 98 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1451-5 Citation Subset: IM |
Affiliation:
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Department of Neonatology and Paediatric Intensive Care, Vest Children's Hospital, University Witten-Herdecke, Datteln, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Chi-Square Distribution Cohort Studies Developmental Disabilities / epidemiology* Fetal Viability Germany / epidemiology Gestational Age Humans Infant Mortality Infant, Newborn Infant, Premature* Infant, Premature, Diseases / mortality* Intensive Care Units, Neonatal Intensive Care, Neonatal / statistics & numerical data* Outcome Assessment (Health Care) / methods* Severity of Illness Index Survival Rate |
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