Document Detail


Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
MedLine Citation:
PMID:  18835035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progress in understanding the molecular pathogenesis of human myeloproliferative disorders (MPDs) has led to guidelines incorporating genetic assays with histopathology during diagnosis. Advances in flow cytometry have made it possible to simultaneously measure cell type and signaling abnormalities arising as a consequence of genetic pathologies. Using flow cytometry, we observed a specific evoked STAT5 signaling signature in a subset of samples from patients suspected of having juvenile myelomonocytic leukemia (JMML), an aggressive MPD with a challenging clinical presentation during active disease. This signature was a specific feature involving JAK-STAT signaling, suggesting a critical role of this pathway in the biological mechanism of this disorder and indicating potential targets for future therapies.
Authors:
Nikesh Kotecha; Nikki J Flores; Jonathan M Irish; Erin F Simonds; Debbie S Sakai; Sophie Archambeault; Ernesto Diaz-Flores; Marc Coram; Kevin M Shannon; Garry P Nolan; Mignon L Loh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer cell     Volume:  14     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-10-16     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cell Proliferation
Cells, Cultured
Child
Disease Progression
Flow Cytometry*
Gene Expression Regulation, Neoplastic
Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
Humans
Janus Kinase 2 / metabolism
Leukemia, Myelomonocytic, Juvenile / genetics,  metabolism*,  pathology,  therapy
Myeloproliferative Disorders / genetics,  metabolism*,  pathology,  therapy
Neoplasm Staging
Phosphorylation
Recurrence
STAT5 Transcription Factor / metabolism*
Signal Transduction* / genetics
Treatment Outcome
Tumor Markers, Biological / metabolism*
Grant Support
ID/Acronym/Agency:
K22 CA113557/CA/NCI NIH HHS; K22 CA113557/CA/NCI NIH HHS; K22 CA113557-01A2/CA/NCI NIH HHS; K22 CA113557-02/CA/NCI NIH HHS; K22 CA113557-03/CA/NCI NIH HHS; N01 HV28183/HV/NHLBI NIH HHS; P01 CA108631/CA/NCI NIH HHS; P01 CA34233/CA/NCI NIH HHS; P30 CA82103/CA/NCI NIH HHS; U54 CA119367/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/STAT5 Transcription Factor; 0/Tumor Markers, Biological; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; EC 2.7.10.2/JAK2 protein, human; EC 2.7.10.2/Janus Kinase 2
Comments/Corrections
Comment In:
Cancer Cell. 2008 Oct 7;14(4):279-80   [PMID:  18835028 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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