Document Detail

Single cell observation of ligand-induced desensitization of B-cell membrane immunoglobulin-mediated calcium signals.
MedLine Citation:
PMID:  1397272     Owner:  NLM     Status:  MEDLINE    
Using a digital imaging fluorescence microscope we have observed the membrane immunoglobulin (mIg)-induced desensitization of calcium signals in individual BAL17 B lymphoma cells which express two kinds of antigen receptors, mIgM and mIgD. The mIgD-mediated desensitization was partly abrogated by pretreating the cells with phorbol 12-myristate 13-acetate (PMA) for 24 h, however, the mIgM-mediated one was not affected by the pretreatment. This supports the idea that at least two mechanisms are operative for mIg-induced desensitization in B cells.
H Yamada; J Mizuguchi; M Noji; M Nakanishi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  310     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-11-04     Completed Date:  1992-11-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  201-3     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
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MeSH Terms
B-Lymphocytes / metabolism*
Calcium / metabolism*
Cell Line
Cell Membrane / metabolism
Immunoglobulins / metabolism*
Microscopy, Fluorescence
Protein Kinase C / metabolism
Signal Transduction
Reg. No./Substance:
0/Immunoglobulins; 0/Ligands; 7440-70-2/Calcium; EC Kinase C

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