| Single cell observation of ligand-induced desensitization of B-cell membrane immunoglobulin-mediated calcium signals. | |
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MedLine Citation:
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PMID: 1397272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using a digital imaging fluorescence microscope we have observed the membrane immunoglobulin (mIg)-induced desensitization of calcium signals in individual BAL17 B lymphoma cells which express two kinds of antigen receptors, mIgM and mIgD. The mIgD-mediated desensitization was partly abrogated by pretreating the cells with phorbol 12-myristate 13-acetate (PMA) for 24 h, however, the mIgM-mediated one was not affected by the pretreatment. This supports the idea that at least two mechanisms are operative for mIg-induced desensitization in B cells. |
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Authors:
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H Yamada; J Mizuguchi; M Noji; M Nakanishi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 310 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-04 Completed Date: 1992-11-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 201-3 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Nagoya City University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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metabolism* Calcium / metabolism* Cell Line Cell Membrane / metabolism Immunoglobulins / metabolism* Ligands Microscopy, Fluorescence Protein Kinase C / metabolism Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Ligands; 7440-70-2/Calcium; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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