Document Detail

Single-breath washouts in a rotating stretcher.
MedLine Citation:
PMID:  11247942     Owner:  NLM     Status:  MEDLINE    
Vital capacity single-breath washouts using 90% O2-5% He-5% SF6 as a test gas mixture were performed with subjects sitting on a stool (upright) or recumbent on a stretcher (prone, supine, lateral left, lateral right, with or without rotation at end of inhalation). On the basis of the combinations of supine and prone maneuvers, gravity-dependent contributions to N2 phase III slope and N2 phase IV height in the supine posture were estimated at 18% and 68%, respectively. Whereas both He and SF6 slope decreased from supine to prone, the SF6-He slope difference actually increased (P = 0.015). N2 phase III slopes, phase IV heights, and cardiogenic oscillations were smallest in the prone posture, and we observed similarities between the modifications of He and SF6 slopes from upright to prone and from upright to short-term microgravity. These results suggest that phase III slope is partially due to emptying patterns of small units with different ventilation-to-volume ratios, corresponding to acini or groups of acini. Of all body postures under study, the prone position most reduces the inhomogeneities of ventilation during a vital capacity maneuver at both inter- and intraregional levels.
M J Rodríguez-Nieto; G Peces-Barba; N G Mangado; S Verbanck; M Paiva
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  90     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-05-31     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1415-23     Citation Subset:  IM; S    
Laboratorio de Fisiopatología Respiratoria, Fundación Jiménez Díaz, Madrid, Spain.
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MeSH Terms
Hemodynamics / physiology
Inspiratory Capacity / physiology
Middle Aged
Nitrogen / metabolism
Posture / physiology*
Prone Position / physiology
Pulmonary Gas Exchange / physiology*
Respiratory Function Tests / instrumentation*
Respiratory Mechanics / physiology*
Supine Position / physiology
Vital Capacity / physiology
Reg. No./Substance:

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