Document Detail

Single breath tracing for carbon dioxide in septic patients with tissue hypoxia.
MedLine Citation:
PMID:  17727266     Owner:  NLM     Status:  MEDLINE    
We investigated whether tissue hypoxia in sepsis produces substantial modifications of convective airway washout and consequently of CO2 transit time. Single breath tracing for carbon dioxide (SBT-CO2) was analysed in 18 ICU septic patients. Nine patients had tissue hypoxia events. Using the Hill formula, all tracings were analysed point by point to obtain the time required for CO2 to achieve 50% maximal value and the Fractional Expiratory Time 50 (FET0.5). Hypoxic patients FET0.5 and CO2 clearance were compared with non-hypoxic patients data. In hypoxic group CvCO2, CO2 clearance and FET0.5 values were higher than in non hypoxic group. During the recovery from hypoxia capnographic parameters did not differ from those recorded in the hypoxic period. CO2 clearance, but not FET0.5, correlated with arterial lactate and base excess either in hypoxic or in recovery period. In conclusion in septic patients tissue hypoxia influences CO2 elimination, modifying SB-CO2 tracing and lengthening FET0.5.
Renzo Zatelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  599     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-30     Completed Date:  2007-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
Dept. of Anesthesia and Intensive Care, University of Ferrara, 44100 Ferrara, Italy.
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MeSH Terms
Anoxia / metabolism*
Capnography / methods*
Carbon Dioxide / metabolism*
Middle Aged
Sepsis / metabolism*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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