Document Detail


Single-breath diffusing capacity of the lung for carbon monoxide: a predictor of PaO2, maximum work rate, and walking distance in patients with emphysema.
MedLine Citation:
PMID:  12740253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The National Emphysema Treatment Trial (NETT) is a randomized, multicenter, clinical trial comparing two different methods of lung volume reduction surgery plus medical therapy to medical treatment alone in patients with advanced emphysema. The purpose of this article was to use the data obtained from the NETT to assess the ability of the single-breath diffusing capacity of the lung for carbon monoxide (DLCO) to predict the need for supplemental oxygen during rest and exercise, as well as overall exercise capacity. METHODS: One thousand seventy-one patients with a mean (+/- SD) FEV(1) of 0.76 +/- 0.24 L were studied. RESULTS: The mean DLCO was 8.0 +/- 3.1 mL/min/mm Hg (28 +/- 10% of predicted). The mean resting PaO(2) was 64 +/- 10 mm Hg. There was a positive association between DLCO and both resting PaO(2) and the requirement for oxygen during a walk at 1 mile per hour (mph). The odds of requiring supplemental oxygen while walking at 1 mph was nine times greater in patients with a DLCO of < or = 20% of predicted than for patients with a DLCO of > 35% of predicted, after adjusting for age and gender. Eighty four percent of individuals with a DLCO of < or = 20% required supplemental oxygen with low levels of exercise compared to 38% of those with a DLCO of > 35%. CONCLUSION: Our results demonstrated that patients with reduced DLCO, particularly when < or = 20% of predicted, are more likely to have reduced PaO(2) at rest and are more likely to require supplemental oxygen with low levels of activity. Thus, DLCO is useful in evaluating whether supplemental oxygen is required for exercise.
Authors:
Zab Mohsenifar; Shing M Lee; Philip Diaz; Gerard Criner; Frank Sciurba; Mark Ginsburg; Robert A Wise
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  123     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-12     Completed Date:  2003-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1394-400     Citation Subset:  AIM; IM    
Affiliation:
Cedars-Sinai Medical Center, Division of Pulmonary/Critical Care Medicine, Los Angeles, CA 90049, USA. mohsenifarz@cshs.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Carbon Monoxide / physiology*
Exercise Tolerance*
Female
Forced Expiratory Volume
Humans
Male
Oxygen / blood
Oxygen Consumption
Oxygen Inhalation Therapy
Pulmonary Diffusing Capacity*
Pulmonary Emphysema / physiopathology*,  therapy
Randomized Controlled Trials as Topic
Vital Capacity
Walking
Grant Support
ID/Acronym/Agency:
N01HR76010/HR/NHLBI NIH HHS; N01HR76101/HR/NHLBI NIH HHS; N01HR761011/HR/NHLBI NIH HHS; N01HR761012/HR/NHLBI NIH HHS; N01HR761013/HR/NHLBI NIH HHS; N01HR761014/HR/NHLBI NIH HHS; N01HR761015/HR/NHLBI NIH HHS; N01HR761016/HR/NHLBI NIH HHS; N01HR761019/HR/NHLBI NIH HHS; N01HR76102/HR/NHLBI NIH HHS; N01HR76103/HR/NHLBI NIH HHS; N01HR76104/HR/NHLBI NIH HHS; N01HR76105/HR/NHLBI NIH HHS; N01HR76106/HR/NHLBI NIH HHS; N01HR76107/HR/NHLBI NIH HHS; N01HR76108/HR/NHLBI NIH HHS; N01HR76109/HR/NHLBI NIH HHS; N01HR76118/HR/NHLBI NIH HHS
Chemical
Reg. No./Substance:
630-08-0/Carbon Monoxide; 7782-44-7/Oxygen

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