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Single-blind, prospective, randomized study of cefmetazole and cefoxitin in the treatment of postcesarean endometritis.
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MedLine Citation:
PMID:  18475417     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to compare the clinical efficacy and safety of cefmetazole given by IV push with that of parenterally administered cefoxitin for the treatment of endometritis following cesarean delivery. METHODS: In a single-blind, multicenter, prospective, randomized study, 355 patients with endometritis after cesarean delivery were enrolled and received medication. Administered was either cefmetazole sodium, 2 g by IV push over 1 min q 8 h, or cefoxitin sodium, 2 g IV q 6 h in a 2:1 ratio. The patients were followed for clinical responses and side effects. RESULTS: The cure rate for cefmetazole was 89% and for cefoxitin it was 79% (P = 0.006). The adverse events were similar in both groups. CONCLUSIONS: Cefmetazole was significantly more effective than cefoxitin in the treatment of endometritis following cesarean delivery.
Authors:
A Chatwani; M Martens; D A Grimes; M Chatterjee; M Noah; M M Stamp-Cole; K T Perry;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Infectious diseases in obstetrics and gynecology     Volume:  3     ISSN:  1064-7449     ISO Abbreviation:  Infect Dis Obstet Gynecol     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  2010-06-30     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  9318481     Medline TA:  Infect Dis Obstet Gynecol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  -    
Affiliation:
Department of Ob/Gyn/REI Temple University Hospital 3401 N. Broad Street, Philadelphia, PA 19140, USA.
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Full Text
Journal Information
Journal ID (nlm-ta): Infect Dis Obstet Gynecol
ISSN: 1064-7449
ISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright ? 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 28 Month: 9 Year: 1994
Accepted Day: 14 Month: 2 Year: 1995
Print publication date: Year: 1995
Volume: 3 Issue: 1
First Page: 28 Last Page: 33
ID: 2364413
PubMed Id: 18475417
Publisher Item Identifier: S1064744995000263
DOI: 10.1155/S1064744995000263

Single-Blind, Prospective, Randomized Study of Cefmetazole and Cefoxitin in the Treatment of Postcesarean Endometritis
Ashwin Chatwani1
Mark Martens2
David A. Grimes3
Molly Chatterjee4
Melvin Noah5
Marion M. Stamp-Cole5
Kimberly T. Perry5
the Cefmetazole Study Group
1Department of Ob/Gyn/REITemple University Hospital3401 N. Broad StreetPhiladelphiaPA19140USA
2University of Texas Medical Branch at GalvestonTXUSA
3University of CaliforniaSan Francisco General HospitalSan FranciscoCAUSA
4University of New Mexico School of MedicineAlbuquerqueNMUSA
5Upjohn CompanyKalamazooMIUSA


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