| Single anticardiolipin measurement in the routine management of patients with systemic lupus erythematosus. | |
| | |
MedLine Citation:
|
PMID: 8151597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To examine the usefulness of a single measurement of anticardiolipin antibodies (aCL) in systemic lupus erythematosus (SLE) in routine clinical practice. METHODS: All 127 patients with SLE currently followed by our rheumatology unit had an aCL measurement on routine clinic review. Their charts were then reviewed for specific disease manifestations. Basic statistical correlations of the aCL result and the specific disease manifestations were performed, and the clinical utility of the aCL test assessed using Bayesian analysis. RESULTS: aCL was positive (> 2 SD) in 24% and was associated with recurrent fetal loss, thrombosis, cerebrovascular disease, livedo reticularis and digital infarcts. Bayesian analysis showed that a single positive aCL test increased the relative and absolute risk of all the above complications. The criterion of aCL positivity as > 15 units (2 SD) was associated with the highest relative risk. CONCLUSION: A single positive aCL test in routine management of SLE is a useful predictor of important clinical events. |
| | |
Authors:
|
R S Axtens; M H Miller; G O Littlejohn; D J Topliss; E F Morand |
Related Documents
:
|
21377747 - Towards a standardised surveillance for trichinella in the european union. 16383727 - Reliability of the 0-1 test for chaos. 15595337 - Potential for personal digital assistant interference with implantable cardiac devices. 20075137 - Testing new devices to help prevent 'misconnection' errors in health care. 15654437 - Detection of entamoeba histolytica/entamoeba dispar in stool specimens by using enzyme-... 17122007 - Prospective evaluation of the hybrid capture 2 and amplicor human papillomavirus (hpv) ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of rheumatology Volume: 21 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1994 Jan |
Date Detail:
|
Created Date: 1994-05-09 Completed Date: 1994-05-09 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 91-3 Citation Subset: IM |
Affiliation:
|
Department of Rheumatology, Monash Medical Centre, Melbourne, Victoria, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Antibodies, Anticardiolipin / analysis* Female Fetal Death / etiology Humans Lupus Erythematosus, Systemic / complications*, immunology* Male Middle Aged Prognosis Recurrence Risk Factors Vascular Diseases / etiology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Anticardiolipin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral lesions in systemic lupus erythematosus detected by magnetic resonance imaging. Relationshi...
Next Document: Characteristics of human immunodeficiency virus and chlorpromazine induced antiphospholipid antibodi...