| Single agent chemotherapy for head and neck cancers. The murine subrenal capsule assay. | |
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MedLine Citation:
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PMID: 6314954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The murine subrenal capsule assay was used to determine chemotherapeutic sensitivities of metastatic, primary, or recurrent head and neck cancers. Tumor fragments (1 cu mm) were implanted under the renal capsule of 2- to 4-month-old normal female C57 BL/6 X DBA/2 F1 hybrid mice. Xenografts included 20 squamous cell carcinomas (SCCs), one mucoepidermoid carcinoma, one adenoid cystic carcinoma, and two melanomas. Groups of tumor-bearing mice were treated with chemotherapy daily for five days. Sensitivities of the tumor were assessed on day 6 by comparison of final implant size with initial implant size. Significant oncolytic activity was detected against 16 of 24 tumors (14 of 20 SCCs and both melanomas). Correlations between the in vivo assay and clinical studies are needed to determine its predictive value. |
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Authors:
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K J McCormick; W R Panje; S Seltzer; R H Merrick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of otolaryngology (Chicago, Ill. : 1960) Volume: 109 ISSN: 0003-9977 ISO Abbreviation: Arch Otolaryngol Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1983-12-17 Completed Date: 1983-12-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376526 Medline TA: Arch Otolaryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 715-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use* Carcinoma / drug therapy Carcinoma, Adenoid Cystic / drug therapy Carcinoma, Squamous Cell / drug therapy Cyclophosphamide / therapeutic use Drug Resistance Female Head and Neck Neoplasms / drug therapy* Humans Kidney / surgery Melanoma / drug therapy Methotrexate / therapeutic use Mice Neoplasm Transplantation |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 50-18-0/Cyclophosphamide; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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