| Single administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline increases the extracellular concentration of dopamine in rat striatum. | |
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MedLine Citation:
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PMID: 19285542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a combined neurochemical and behavioral study to determine the effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1-BnTIQ) on the extracellular dopamine concentrations in the striatum. Single dose administration of 1-BnTIQ (20, 40, and 80 mg/kg i.p.) increased striatal dopamine extracellular levels in a dose-dependent manner when an in vivo microdialysis technique was used to assess dopamine levels in the striatum of rats. Enhancement of striatal dopamine levels by systemic administration of a single dose of 1-BnTIQ was suppressed by perfusion of tetrodotoxin and a calcium ion-free solution into the striatum. This 1-BnTIQ-induced increase in extracellular dopamine concentration was also inhibited by pre-treatment with a dopamine uptake inhibitor, GBR12909 (1-(2-[bis(4-Fluorophenyl)-4-(3-phenylpropyl)piperazine dihydrochloride). Local application of 1-BnTIQ into the striatum via a dialysis probe failed to enhance the extracellular concentration of dopamine. However, microinjection of 1-BnTIQ into the substantia nigra pars compacta increased the extracellular dopamine levels in the striatum. Locomotor activity was increased by systemic administration of a single dose of 1-BnTIQ in a dose-dependent manner. This 1-BnTIQ-induced locomotor activity was attenuated by pre-treatment with SCH23390 (R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochlodride) and raclopride, D(1) and D(2) dopaminergic receptor antagonists, respectively. Moreover, 1-BnTIQ induced ipsilateral rotational behavior in 6-hydroxydopamine-lesioned rats. These results suggest that systemic administration of a single dose of 1-BnTIQ increases striatal extracellular dopamine concentration through activation of dopaminergic nigra striatal neurons via the dopamine transporter. |
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Authors:
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N Katagiri; K Abe; M Kitabatake; I Utsunomiya; Y Horiguchi; K Hoshi; K Taguchi |
Publication Detail:
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Type: Journal Article Date: 2009-03-12 |
Journal Detail:
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Title: Neuroscience Volume: 160 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 820-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacotherapeutics, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corpus Striatum / drug effects*, metabolism Dopamine / metabolism*, secretion Dopamine Antagonists / pharmacology Dopamine Plasma Membrane Transport Proteins / drug effects, metabolism Dopamine Uptake Inhibitors / pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Extracellular Fluid / drug effects, metabolism Male Microdialysis Motor Activity / drug effects, physiology Neurons / drug effects*, metabolism, secretion Oxidopamine / pharmacology Rats Rats, Wistar Sodium Channel Blockers / pharmacology Substantia Nigra / drug effects, metabolism Sympatholytics Tetrahydroisoquinolines / pharmacology* Tetrodotoxin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Dopamine Plasma Membrane Transport Proteins; 0/Dopamine Uptake Inhibitors; 0/Sodium Channel Blockers; 0/Sympatholytics; 0/Tetrahydroisoquinolines; 1199-18-4/Oxidopamine; 19716-56-4/1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline; 4368-28-9/Tetrodotoxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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