| A single progenitor population switches behavior to maintain and repair esophageal epithelium. | |
| | |
MedLine Citation:
|
PMID: 22821983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diseases of the esophageal epithelium (EE), such as reflux esophagitis and cancer, are rising in incidence. Despite this, the cellular behaviors underlying EE homeostasis and repair remain controversial. Here, we show that in mice, EE is maintained by a single population of cells that divide stochastically to generate proliferating and differentiating daughters with equal probability. In response to challenge with all-trans retinoic acid (atRA), the balance of daughter cell fate is unaltered, but the rate of cell division increases. However, after wounding, cells reversibly switch to producing an excess of proliferating daughters until the wound has closed. Such fate-switching enables a single progenitor population to both maintain and repair tissue without the need for a "reserve" slow-cycling stem cell pool. |
| | |
Authors:
|
David P Doupé; Maria P Alcolea; Amit Roshan; Gen Zhang; Allon M Klein; Benjamin D Simons; Philip H Jones |
Related Documents
:
|
2394013 - Morphological and electrophysiological correlates of atrioventricular nodal response to... 1685973 - Voltage-activated currents in the cri-g1 rat insulin-secreting cell-line. 17640303 - Cleavage of growth differentiation factor 15 (gdf15) by membrane type 1-matrix metallop... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-07-19 |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 337 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-08-31 Completed Date: 2012-09-17 Revised Date: 2013-05-27 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
|
Languages: eng Pagination: 1091-3 Citation Subset: IM |
Affiliation:
|
Medical Research Council (MRC) Cancer Cell Unit, Hutchison-MRC Research Centre, Cambridge, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Markers / analysis Cell Differentiation / drug effects Cell Division / drug effects Cell Proliferation / drug effects Cells, Cultured Doxycycline / pharmacology Epithelial Cells / physiology* Epithelium / drug effects, metabolism, physiology* Esophagus / cytology*, physiology* Green Fluorescent Proteins / biosynthesis Histones / biosynthesis Mice Mice, Inbred C57BL Recombinant Fusion Proteins / biosynthesis Regeneration* Stem Cells / metabolism, physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
G0601740//Medical Research Council; MC_U105370181//Medical Research Council; U.1053.00.010(70181)//Medical Research Council; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Histones; 0/Recombinant Fusion Proteins; 0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins; 564-25-0/Doxycycline |
| Comments/Corrections | |
Comment In:
|
Cell Stem Cell. 2012 Sep 7;11(3):284-6
[PMID:
22958926
]
EMBO J. 2012 Sep 12;31(18):3653-4 [PMID: 22885597 ] Science. 2012 Aug 31;337(6098):1051-2 [PMID: 22936766 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.
Next Document: A Reversible and Higher-Rate Li-O2 Battery.