| Single nucleotide polymorphisms that affect homocysteine levels in Turkish population. | |
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MedLine Citation:
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PMID: 18796460 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, single nucleotide polymorphisms (SNPs) involved in homocysteine metabolism such as CT replacement in the 677th nucleotide in 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme; 68-bp insertion in the 844th nucleotide of cystathionine beta-synthase (CBS) enzyme; 6-bp insertion/deletion in the region of 3'UTR in thymidylate synthase (TYMS) enzyme and 19-bp deletion in dihydrofolate reductase (DHFR) enzyme were investigated. The effects of these mutations on homocysteine levels were studied. As a result; we found that TT genotype of MTHFR 677 CT is an influencing factor on homocysteine levels in Turkish population. Furthermore, there seems to be another MTHFR 677 TT haplotype, which does not have an effect on homocysteine levels. Our data revealed that other SNPs did not have any influence on homocysteine levels. |
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Authors:
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Yasemin L Ko??; Nejat Akar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-15 |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 15 ISSN: 1938-2723 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 701-4 Citation Subset: IM |
Affiliation:
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Pediatric Molecular Genetic Department, Ankara University Medical School, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Distribution Aged Aged, 80 and over Cystathionine beta-Synthase / genetics Female Homocysteine / blood*, metabolism Humans Male Metabolic Networks and Pathways / genetics Methylenetetrahydrofolate Reductase (NADPH2) / genetics* Middle Aged Polymorphism, Single Nucleotide* Tetrahydrofolate Dehydrogenase / genetics Thymidylate Synthase / genetics Turkey / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 1.5.1.3/Tetrahydrofolate Dehydrogenase; EC 2.1.1.45/Thymidylate Synthase; EC 4.2.1.22/Cystathionine beta-Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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