| A single dose of esmolol blunts the increase in bispectral index to tracheal intubation during sevoflurane but not desflurane anesthesia. | |
| | |
MedLine Citation:
|
PMID: 19542998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Activation of the peripheral nerve system by endotracheal intubation is accompanied by an increase in bispectral index (BIS). Esmolol produces a dose-dependent attenuation of the adrenergic response to endotracheal intubation. Desflurane increases sympathetic nerve activity and plasma norepinephrine relative to sevoflurane. The authors hypothesized that esmolol might blunt the BIS response to endotracheal intubation more during sevoflurane anesthesia than desflurane anesthesia. In this double blind, randomized study, after the induction of anesthesia, patients were mask-ventilated with either sevoflurane or desflurane (end-tidal 1 minimum alveolar concentration) and received normal saline or esmolol (0.5 mg/kg) 1 minute before intubation (sevoflurane-control, sevoflurane-esmolol, desflurane-control, and desflurane-esmolol groups, n=20/group). BIS, mean arterial pressure, and heart rate were measured before the induction of anesthesia (awake), before esmolol injection (time point -1), immediately before intubation (time point 0), and every minute for 5 minutes after tracheal intubation (time point 1 to 5). Compared with preintubation, esmolol attenuated the increase in BIS at 1 minute after intubation during sevoflurane anesthesia (5.1% for esmolol and 31.7% for control) but not during desflurane anesthesia (28.6% for esmolol and 30.8% for control). Mean arterial pressure and heart rate increased after intubation in all groups but the changes were greater in the control groups than the esmolol groups. In conclusion, a single dose of esmolol blunted the increase in BIS to tracheal intubation during sevoflurane but not desflurane anesthesia. |
| | |
Authors:
|
Seung Ho Choi; Chang Seok Kim; Jong Hoon Kim; Bum Su Kim; Eun Mi Kim; Kyeong Tae Min |
Related Documents
:
|
16460338 - Effects of regional anesthesia with ropivacaine on arterial pressure and heart rate in ... 19795938 - Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetiz... 2035928 - Comparison of the hemodynamic effects of halothane alone and halothane combined with ep... 11493488 - Effects of desflurane on cerebral autoregulation. 18639638 - Local ras and inflammatory factors are involved in cardiovascular hypertrophy in sponta... 14621188 - Central cardiovascular action of urotensin ii in spontaneously hypertensive rats. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of neurosurgical anesthesiology Volume: 21 ISSN: 1537-1921 ISO Abbreviation: J Neurosurg Anesthesiol Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-22 Completed Date: 2009-08-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8910749 Medline TA: J Neurosurg Anesthesiol Country: United States |
Other Details:
|
Languages: eng Pagination: 214-7 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenergic beta-Antagonists / therapeutic use* Adult Aged Anesthesia, Inhalation* Anesthetics, Inhalation* Blood Pressure / drug effects Double-Blind Method Electroencephalography / drug effects* Female Heart Rate / drug effects Humans Intubation, Intratracheal* Isoflurane / analogs & derivatives* Male Methyl Ethers* Middle Aged Propanolamines / therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Anesthetics, Inhalation; 0/Methyl Ethers; 0/Propanolamines; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 57041-67-5/desflurane; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early postoperative cognitive recovery and gas exchange patterns after balanced anesthesia with sevo...
Next Document: Evaluation of the FloTrac Uncalibrated Continuous Cardiac Output System for Perioperative Hemodynami...