| Single-Center Kidney Paired Donation: The Methodist San Antonio Experience. | |
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MedLine Citation:
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PMID: 22548839 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Many potential kidney transplant recipients are unable to receive a live donor transplant due to crossmatch or blood type incompatibility. Kidney paired donation increases access to live donor transplantation but has been significantly underutilized. We established a kidney paired donation program including consented incompatible donor/recipient pairs as well as compatible pairs with older non-human leukocyte antigen identical donors. Over a 3-year period, a total of 134 paired donor transplants were performed, including 117 incompatible pairs and 17 compatible pairs. All transplants were done with negative flow cytometry crossmatches and five were done with desensitization combined with paired donation. Kidney paired donation transplants included two-way and three-way exchanges as well as three chains initiated by nondirected donors. Of the sensitized recipients transplanted by paired donation, 44% had calculated panel reactive antibody levels greater than 80%. Transplantation of females and prior transplant recipients was significantly higher with paired donation. Only three episodes of rejection occurred and no transplants were lost due to rejection. These data highlight the potential of kidney paired donation and suggest that all transplant centers should be actively engaged in paired donation to increase access to live donor transplantation. |
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Authors:
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A W Bingaman; F H Wright; M Kapturczak; L Shen; S Vick; C L Murphey |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-30 |
Journal Detail:
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Title: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Volume: - ISSN: 1600-6143 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100968638 Medline TA: Am J Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons. |
Affiliation:
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Methodist Specialty and Transplant Hospital, San Antonio, TX Southwest Immunodiagnostics Inc., San Antonio, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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